In my opinion, the mass effect series tops it due to its amazing writing and story driven nature. However, it's rpg elements were not as strong as some other titles, so which one did you enjoy the most?
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My favorite was Mass Effect. I don't know if it was the best though. Actually, most of those poll options don't count. Fable came out on the original Xbox, making it 2 generations old, Fallout is almost 20 years old, Final Fantasy is older still. TES is also way too old to be "last gen".