Bungie dev already said on Twitter that there will be an adventure that we do for and interact with variks. He also let slip that the raid boss is female. Make of that what you will. Also, another protagonist that we love to hate would be handsome jack in borderlands 2 and his downfall in the pre sequel.
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Which one?! Tell me how to see it I WANT PROOF
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<Ah, I agree with that. Handsome Jack was great.>