So today I unlocked the Defender subclass for Titan (obviously level 15) and its stats start way lower than my upgraded Striker stats. Should I make the switch, and when? I feel like a transition would be quite difficult with such lower armour
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I'd say finish leveling your striker class first, then work on finishing your defender class. The defender class has more armor overall. It also depends on your playstyle, as striker, you can use the super to wipe out large groups. As defender, you can gain armor or weapon buffs through super (Coupled with the Saint-14 you can blind enemies that come through your bubble). It's good having both fully leveled so that you can swap around when you need to.