To add more variety it would be great if the bosses moved around the planets, so weekly missions wouldn't just be the same missions re-hashed over and over. Instead they would be along the lines of "Sepkis Prime has appeared near the hellmouth, hunt him down and eradicate him" or "An Archon Priest is attempting to enter the Black Garden, destroy his guards and stop his advance"
These could just be stand alone boss battles, no gauntlet type fights.
OH OH OH
"Phogarth has escaped to earth, he is advancing on the Devils Lair" This would be Sepkis Prime V Phogarth, both of them duking it out, with you in the middle trying to kill them both, such fun would be had.
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They can't move because I killed them 100 times.
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That'll be in DLC. ;)