So, I just saw the Amazing Spider-Man and judging by its success (and knowing Marvel/Disney), I'm willing to bet there will be more sequels starring Andrew Garfield. It hasn't been announced, but they would be stupid not to make a second one.
But, the big question is what villain(s) will star in a second movie. My hope is Kraven the Hunter, Shocker, the Enforcers, Mysterio, or Chameleon. What do you think, Flood?
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Mister Osborn would like to have a word with you. On a slightly unrelated note: IRON MAN 3 EXTREMIS ARMOR WOO