I think I have a tie between Native Son and The Great Gatsby. I swear if it wasn't for Sparknotes and Google I would've failed my Literature classes. I never even read a single chapter of any of those novels.
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I actually like Gatsby and Grapes, and the Shakespeare I read (Julius Caesar, Othello, King Lear). On the other hand, I hated The Scarlet Letter, Ethan Frome, and Antigone. I know the last one was a play, but whatever.