Mine has been in "The Summoning Pits" on Moon, called "The Untamed". Ridiculous health, constant high damage beams and never resting minion waves. It's not impossible, but if you get there low level and no back-up, better say your prayers haha
So, what's your most hated boss nemesis?
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By far, the hardest boss I have yet to face is Glitcheon and her evil sister lagta. They like to follow me into boss rooms and sometimes... if Im really lucky, they decide to attack together. Personal favorite is being teleported into the air above the platform, in the past portal with HM atheon... with a detain bubble. Well played Glitcheon. Well played.