Why not, if she doesn't have a physical form why not redesign her voice and 'body' to be a male should she ever be rebuilt. Get a bromance thing going on with Master Chief.
Edit: Didn't expect this to get bumped. Still a rousing topic, should be discussed.
-
Well, going by canon, she [i]should[/i] be a female, as she is the most prominent resemblance to Dr. Hasley.