Invisibility works great in PvE, but that's because the enemies are programed to ignore you. In the few instances where I can view my character in third person i'm not really all that invisible. Even when standing completely motionless you're still quite blue. I've tried using it in the Crucible and i'm being spotted almost instantly regardless.
Is there any practical use to trying to use invisibility against real flesh and blood players with eyeballs or should it just be ignored in favor of other skills when in PvP?
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Invicibility is beneficial in PvP if you are proficient. If you can use your invicibility to gain a split second advantage by pulling your trigger first in a gun fight it is worth it.