Depends on some variables really. Rolling solo, wife/gf, kids, bros/sis. Budget restrictions? White water rafting is always a good time if your into stuff like that. Do you surf, camp, hike, or are museums more your type of thing? DC is a good place for history and museums. Motorcycling through the Blue Ridge Parkway is fun. Staying in a cabin in Asheville NC is something I always personally enjoyed. Last time I went there, several years ago, it wasn't overrun by tourists and is georgeous when the leaves are changing.