Malwarebytes and Combofix are top notch. Malwarebytes is free, but a paid version allows passive protection. The free version will let you initiate scans, and will catch almost anything.
Combofix is a bit more powerful, but it has the potential to mess up your system if you don't know what you're doing.
malwarebytes.org ... I can't link a .org, I guess.
[url]http://www.bleepingcomputer.com/download/combofix/[/url]
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You can also get the current version from CNET's download.com