subjective of course, so [i]my[/i] best gaming mouse may not be best to someone else. For me it is the Razer naga 2013 edition. Yes, I do actually use all 20 buttons on the side and I'm not just saying that. Even when not playing games I have a profile for design stuff like simple commands such as cut, copy, paste, delete, and enter so I don't have to use the keyboard for simple commands when in design programs. Even on web browsers it's nice to be able to copy urls or text in a single button click and as fast as that another button click paste it. Workflow increased drastically =) When gaming I put a ton of useful stuff on the buttons as well. Games like BF4 that have extra add-ons and options it works handy for tossing about health/ammo or switching to different weapons quickly. RPG games it's even more useful as I can put every menu and preset I want on the buttons.