Pretty simple question. Feel free to comment and explain your choice.
Trying to only take into account PvE (PvP opinions are welcome, but the argument about balance tends to rage harder in PvP threads so my goal is to keep it PvE focused).
Also, this is about primary weapons only. I fully understand incredible PvE weapons like the Ice Breaker are often considered to be a must have in endgame PvE. Just focusing on the primary weapons on this one though (maybe I'll run another poll later for secondaries and heavy's).
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Cryptic Dragon Scout Rifle with headshot explosive rounds. You can control a pack of minions with this baby. One or two headshots and the rest of the enemies around dies because the explosions.