First I'd like to say I find your multiplayer very fun in its current iteration but I find your single-player lacking (please, please make the tutorial shorter and give you all the weapons/supers/ect. you need in multiplayer to be on an even field in the tutorial). This post's changes will be directed only at multiplayer however.
1) Buff shotgun one shot kill range slightly.
I feel that the endgame best items in retail might make the game a little too much like Call of Duty. I don't think many of us want that (example: Halo 4). In the alpha you choose shotgun and loose at range or you choose rifle and lose up close. It was a magical part of the game and now it's 65% (from 55%) rifle and 35% (from 45%) shotgun.
2) Buff splash range of Titan's super.
You nerfed the invincibility from the Alpha (and that's good) but didn't give anything in return. The Warlock's super has about the same amount of invincibility but can be used at range so it deserves this.
3) Nerf aim-assist on Hunter's super.
The Hunter's super has the most potential so it needs to be made a little harder to use without nerfing the damage.
4) Remove bonuses (green item leveling, armour durability and intelligence bonuses, ect.) from armour in matchmaking.
In all honesty I'm not sure if this has already been done but if it hasn't it should be to reduce grinding when people find the endgame best weapons.
I'd like to note that the weapons are reasonably balanced already, except the shotgun which could use a small range buff (listed above). People can jump in and play with whatever guns they want and have an okay chance. You do not need to balance them for high level players because they will find and grind the best endgame setup anyway.
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Yeah all of that is bad. Don't listen to any of this.