I'm predicting that in a couple years, when 343 has the time it needs to shoot out a game that bears the full potential of it's talent, it will win GOTY. It should get Halo back on track after Halo 4, which was nothing but a minor speed bump in an otherwise beautiful game franchise.
Also, GTA 5 and Splinter Cell should duke in out next year for GOTY.
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I predict that it won't win. I think those odds are better.